ORIGINAL_ARTICLE
Prothrombin G20210A Mutation is not a Risk Factor for Pediatric Acute Lymphoblastic Leukemia in Western Iran
Background: We conducted the present study to investigate the frequency of prothrombin G20210A mutation among acute lymphoblastic leukemia patients and healthy individuals from Western Iran and to detect the possible association between this mutation and the risk of acute lymphoblastic leukemia in our population.Methods: The studied groups consisted of 92 children with acute lymphoblastic leukemia and 249 age- and sex-matched healthy children from Western Iran. The prothrombin G20210A mutation was identified by PCR-RFLP using the restriction enzyme of Hind III.Results: The prevalence of prothrombin 20210 GA genotype was 6.5% in patients and 3.2% in controls (P=0.17). The frequency of the A allele in patients was 3.3% and in controls it was1.6%.Conclusion: The present study indicates the absence of any significant differences in the frequency of the prothrombin G20210A mutation between acute lymphoblastic leukemia patients and healthy individuals. The results suggest that this mutation may not be a risk factor for acute lymphoblastic leukemia in our population.
https://mejc.sums.ac.ir/article_41933_76d16722fa50b94c58f9809b6d4dc6f6.pdf
2013-10-01
139
143
Zohreh
Rahimi
zrahimi@kums.ac.ir
1
Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
LEAD_AUTHOR
Ziba
Rahimi
zrahimi1980@hotmail.com
2
Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
AUTHOR
Reza
Akramipour
3
Department of Pediatrics, Kermanshah University of Medical Sciences, Kermanshah, Iran
AUTHOR
ORIGINAL_ARTICLE
Evaluation of the Effect of a Preoperative Single Dose of Gabapentin on Emergence Agitation in Patients Undergoing Breast Cancer Surgery
Background: Emergence agitation is a transient confusional state that usually occurs within 10 to 30 minutes of recovery from general anesthesia. It may lead to serious consequences and increasing hospital costs. This study evaluates the effect of gabapentin on emergence agitation in patients undergoing breast cancer surgery.Methods: This randomized, double blind controlled trial enrolled 100 female patients with American Society of Anesthesiologists' classifications I and II who were candidates for breast cancer surgery. Patients were randomly assigned into two groups (n=50) that received either oral gabapentin 600 mg or placebo. Induction and maintenance of anesthesia were similar in both groups. At the end of surgery, patient's agitation score, pain score, and presence of nausea or vomiting were reported. In the ward, the presence of headache or dizziness was checked during the first 8 h. Mann- Whitney test was used for comparison of agitation and pain scores between two groups. Chi-square test was used for comparing occurrence of nausea, vomiting and qualitative. The qualitative demographic variable and t-test compared quantitative demographic variables.Results: There was a significantly lower incidence of emergence agitation in the gabapentin group before (P<0.001) and after (P=0.029) extubation. There were significantly lower mean agitation scores before (P<001) and after (P=0.006) extubation and in the pain score (P=0.005) in the gabapentin group. The need for remifentanil infusion (P<0.05) during surgery was significantly lower in the gabapentin group compared with the placebo group. Occurrence of nausea and vomiting and gabapentin side effects that included headache or dizziness did not significantly differ between two groups (P=0.126, P=1, P=0.629 respectively).Conclusion: Gabapentin not only decreased postoperative pain but also effectively reduced emergence agitation without any significant side effects in patients undergoing breast cancer surgery.
https://mejc.sums.ac.ir/article_41934_fe58415f2f99a26c4956a26965314b39.pdf
2013-10-01
145
151
Simin
Azemati
azemati@sums.ac.ir
1
Shiraz Anesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Abbas
Gholami Dokouhaki
2
Shiraz Anesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Abdolrasoul
Talei
taleiar@gmail.com
3
Department of Surgery, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Saeed
Khademi
khademisaied@yahoo.com
4
Shiraz Anesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
LEAD_AUTHOR
Nader
Moin-Vaziri
5
Department of Surgery, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
ORIGINAL_ARTICLE
Classifying Pediatric Central Nervous System Tumors through near Optimal Feature Selection and Mutual Information: A Single Center Cohort
Background: Labeling, gathering mutual information, clustering and classification of central nervous system tumors may assist in predicting not only distinct diagnoses based on tumor-specific features but also prognosis. This study evaluates the epidemi- ological features of central nervous system tumors in children who referred to Mahak’s Pediatric Cancer Treatment and Research Center in Tehran, Iran.Methods: This cohort (convenience sample) study comprised 198 children (≤15 years old) with central nervous system tumors who referred to Mahak's Pediatric Cancer Treatment and Research Center from 2007 to 2010. In addition to the descriptive analyses on epidemiological features and mutual information, we used the Least Squares Support Vector Machines method in MATLAB software to propose a preliminary predictive model of pediatric central nervous system tumor feature-label analysis.Results:Of patients, there were 63.1% males and 36.9% females. Patients' mean±SD age was 6.11±3.65 years. Tumor location was as follows: supra-tentorial (30.3%), infra- tentorial (67.7%) and 2% (spinal). The most frequent tumors registered were: high-grade glioma (supra-tentorial) in 36 (59.99%) patients and medulloblastoma (infra-tentorial) in 65 (48.51%) patients. The most prevalent clinical findings included vomiting, headache and impaired vision. Gender, age, ethnicity, tumor stage and the presence of metastasis were the features predictive of supra-tentorial tumor histology.Conclusion: Our data agreed with previous reports on the epidemiology of central nervous system tumors. Our feature-label analysis has shown how presenting features may partially predict diagnosis. Timely diagnosis and management of central nervous system tumors can lead to decreased disease burden and improved survival. This may be further facilitated through development of partitioning, risk prediction and prognostic models.
https://mejc.sums.ac.ir/article_41936_c87cf2064185de568b1593dfa77bfa1a.pdf
2013-10-01
153
162
Mohammad
Faranoush
1
MAHAK Pediatric Cancer Treatment and Research Center (MPCTRC), Tehran, Iran
AUTHOR
Mohammad
Torabi-Nami
torabinami@sums.ac.ir
2
School of Advanced Medical Science and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran
LEAD_AUTHOR
Azim
Mehrvar
3
MAHAK Pediatric Cancer Treatment and Research Center (MPCTRC), Tehran, Iran
AUTHOR
Amir Abbas
HedayatiAsl
4
MAHAK Pediatric Cancer Treatment and Research Center (MPCTRC), Tehran, Iran
AUTHOR
Maryam
Tashvighi
5
MAHAK Pediatric Cancer Treatment and Research Center (MPCTRC), Tehran, Iran
AUTHOR
Reza
Ravan Parsa
6
Islamic Azad University, Tehran, Iran
AUTHOR
Mohammad Ali
Fazeli
7
MAHAK Pediatric Cancer Treatment and Research Center (MPCTRC), Tehran, Iran
AUTHOR
Behdad
Sobuti
8
MAHAK Pediatric Cancer Treatment and Research Center (MPCTRC), Tehran, Iran
AUTHOR
Narjes
Mehrvar
narjes.mehrvar@gmail.com
9
MAHAK Pediatric Cancer Treatment and Research Center (MPCTRC), Tehran, Iran
AUTHOR
Ali
Jafarpour
10
MAHAK Pediatric Cancer Treatment and Research Center (MPCTRC), Tehran, Iran
AUTHOR
Rokhsareh
Zangooei
11
MAHAK Pediatric Cancer Treatment and Research Center (MPCTRC), Tehran, Iran
AUTHOR
Mardawij
Alebouyeh
12
MAHAK Pediatric Cancer Treatment and Research Center (MPCTRC), Tehran, Iran
AUTHOR
Mohammadreza
Abolghasemi
13
School of Cognitive Sciences, Institute for Research in Fundamental Sciences (IPM), Tehran, Iran
AUTHOR
Abdol-Hossein
Vahabie
14
School of Cognitive Sciences, Institute for Research in Fundamental Sciences (IPM), Tehran, Iran
AUTHOR
Parvaneh
Vossough
15
MAHAK Pediatric Cancer Treatment and Research Center (MPCTRC), Tehran, Iran
AUTHOR
ORIGINAL_ARTICLE
The Apoptotic Effects of the P300 Activator on Breast Cancer and Lung Fibroblast Cell Lines
This article (Mohammad Reza Salahshoor, Cyrus Jalili, Ahmad Shebanizadeh Darehdori, Mozafar Khazaei, Shiva Roshankhah, Rostam Ghorbani, The Apoptotic Effects of the P300 Activator on Breast Cancer and Lung Fibroblast Cell Lines, Middle East Journal of Cancer, 2013,4(4): 163-173) has been retracted by agreement between the authors, the journal’s editors and the publisher. The authors have contacted the editor-in-chief and mentioned that this article was previously published in another journal without their awareness and that was an inadvertent event.
https://mejc.sums.ac.ir/article_41938_0d9d026aa420627c1b288c280dfa30e5.pdf
2013-10-01
163
173
Mohammad Reza
Salahshoor
salahshoor@kums.ac.ir
1
Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
AUTHOR
Cyrus
Jalili
cjalili@yahoo.com
2
Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
LEAD_AUTHOR
Ahmad
Shebanizadeh Darehdori
3
Department of Anatomical Sciences and Molecular Biology,Rafsanjan University of Medical Sciences, Rafsanjan, Iran
AUTHOR
Mozafar
Khazaei
mkhazaei1345@yahoo.com
4
Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
AUTHOR
Shiva
Roshankhah
roshankhah@yahoo.com
5
Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
AUTHOR
Rostam
Ghorbani
6
Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
AUTHOR
ORIGINAL_ARTICLE
Cytotoxic Effect of Luteolin on Human Colorectal Cancer Cell Line (HCT-15): Crucial Involvement of Reactive Oxygen Species
Background: Colorectal cancer, a major health concern worldwide, is the third most common form of cancer and second leading cause of cancer-related deaths. The flavonoids are naturally occurring diphenylpropanoids ubiquitous in plant foods and important components of the human diet. Luteolin, a bioflavonoid, possesses many beneficial effects including antioxidant, anti-inflammatory, anti-allergic activities. Methods:We used the HCT-15 colon adenocarcinoma cell line in this study. Cells were treated with luteolin (100 µM).Results: Membrane damage markers such as alkaline phosphatase and lactate dehydrogenase were analyzed in a time-dependent manner. Luteolin increased reactive oxygen species in a time-dependent manner. DNA damage, a hallmark of apoptosis, was induced by luteolin as analyzed by agarose gel electrophoresis.Conclusion: Luteolin acts as a potential cytotoxic agent that can be used to treat colorectal cancer.
https://mejc.sums.ac.ir/article_41932_91e4bc98de1fca8e93fb1ed87d598b98.pdf
2013-10-01
175
180
Ashok
Pandurangan
panduashokkumar@gmail.com
1
Department of Biochemistry, University of Madras, Chennai, Tamil Nadu, India
LEAD_AUTHOR
Sudhandiran
Ganapasam
2
Department of Biochemistry, University of Madras, Chennai, Tamil Nadu, India
AUTHOR
ORIGINAL_ARTICLE
Large Phyllodes Tumor: A Case Report
Phyllodes tumors account for less than 1% of breast tumors in women. Giant phyllodes tumors are larger than 10 cm in diameter. A 40-year-old lady presented with a left breast lump that was present for two years. She underwent a simple mastectomy. The tumor was 30×26×21 cm in size, weighed 15 kg and had a density of 0.915 gr/cm3. We believe this patient had the third largest breast phyllodes tumor according to size, the second largest according to weight and had the highest density among all cases thus reported in English-language publications.
https://mejc.sums.ac.ir/article_41931_ff6d7d4eb8ad401453a80d11a69b51a9.pdf
2013-10-01
181
184
Sedigheh
Tahmasebi
tahmasebikh@gmail.com
1
Department of Surgical Oncology, Faghihi Hospital, Shiraz, Iran
AUTHOR
Majid
Akrami
akramimd@yahoo.com
2
Department of Surgical Oncology, Faghihi Hospital, Shiraz, Iran
AUTHOR
Sam
Moslemi
moslemis@sums.ac.ir
3
General Surgery Department, Shiraz University of Medical Sciences, Shiraz, Iran
LEAD_AUTHOR
Maryam
Tahamtan
4
Department of Internal Medicine, Nemazee Teaching Hospital, Shiraz, Iran
AUTHOR
Mohammad Hasan
Hashemizadeh
5
Department of Internal Medicine, Nemazee Teaching Hospital, Shiraz, Iran
AUTHOR
ORIGINAL_ARTICLE
Cervical Lymphadenopathy as the First Presentation of Sigmoid Colon Cancer
The most common metastatic sites for colorectal carcinomas include the liver, lungs, brain, bones and peritoneal surfaces. In this report, a case of sigmoid colon carcinoma presented with cervical lymphadenopathy was detected with the help of PET/CT. A 57 year-old male presented with a complaint of swelling on the left side of his neck. Ultrasonographic examination of the neck revealed three hypoechoic, peripherally vascularized lymph nodes with the largest diameter of 3cm. The thyroid gland was normal. Fine needle aspiration biopsy was performed and the pathology result was a metastatic carcinoma. He underwent a PET/CT scan to search for the primary carcinoma which showed increased standardized uptake value of 13.2 in the left colon and 10.8 in the left cervical region. Colonoscopy showed an ulcerated mass lesion with obstruction of the lumen in the sigmoid colon.The patient had an anterior resection of the sigmoid colon with simultaneous resection of cervical lymph nodes. There was no evidence of intra-abdominal dissemination during surgery. The lymph nodes removed from the neck were also reportedas metastatic adenocarcinoma. The patient underwent six cycles of adjuvant FOL FOX chemotherapy regimen. The patient has remained disease free after nine months of follow-up. PET/CT was a quick, effective method for the detection of the primary tumor in the sigmoid colon. In additional to colonic resection and systemic therapy, palliative local control can also be achieved with the excision of metastatic lymph nodes in the neck.
https://mejc.sums.ac.ir/article_41935_880130a6a3686e2482ba5eac2f32cfb1.pdf
2013-10-01
185
188
Bulent
Aksel
bulnet@sums.ac.ir
1
Department of General Surgery, Ankara Oncology Training and Education Hospital, Ankara, Turkey
AUTHOR
Lutfi
Dogan
lutfidogan1@gmail.com
2
Department of General Surgery, Ankara Oncology Training and Education Hospital, Ankara, Turkey
LEAD_AUTHOR
Niyazi
Karaman
niyazikaraman@hotmail.com
3
Department of General Surgery, Ankara Oncology Training and Education Hospital, Ankara, Turkey
AUTHOR
Salim
Demirci
4
Department of Surgical Oncology, Ankara University, School of Medicine, Ankara,Turkey
AUTHOR
ORIGINAL_ARTICLE
Leiomyoma of the Female Urethra with Intermittent Urinary Retention: A Case Report
Urethral leiomyomas are rare begin mesenchymal tumors that arise from the smooth muscle of the urethra. Most reported cases in the literature have occurred in women of child bearing age. These tumors present with a variety of symptoms. Excision is curative however occasional cases of relapse have been described. Here we describe a case of a female teenager who presented with intermittent urinary retention and final histopathological diagnosis of leiomyoma of the distal urethra following excision. She had an uneventful recovery and has remained completely symptom-free. To the best of our knowledge, this is first case of urethral leiomyoma in Pakistan that has presented with a history of recurrent urinary retention.
https://mejc.sums.ac.ir/article_41937_c9aa1ff13e61ddddfca4b1bc70cf7359.pdf
2013-10-01
189
192
Rukhsana
Aslam
1
Urology Department, Sindh Institute of Urology and Transplantation, Civil Hospital, Karachi, Pakistan
AUTHOR
Rehan
Mohsin
2
Urology Department, Sindh Institute of Urology and Transplantation, Civil Hospital, Karachi, Pakistan
AUTHOR
Muhammed
Mubarak
drmubaraksiut@yahoo.com
3
Histopathology Department, Sindh Institute of Urology and Transplantation, Civil Hospital, Karachi, Pakistan
LEAD_AUTHOR
Altaf
Hashmi
4
Urology Department, Sindh Institute of Urology and Transplantation, Civil Hospital, Karachi, Pakistan
AUTHOR
Adeebul Hassan
Rizvi
5
Urology Department, Sindh Institute of Urology and Transplantation, Civil Hospital, Karachi, Pakistan
AUTHOR
ORIGINAL_ARTICLE
Calendar of Events
https://mejc.sums.ac.ir/article_41930_641b4f28c1a39818ddbe983d22fce763.pdf
2013-10-01
193
193