eng
Shiraz University of Medical Sciences
Middle East Journal of Cancer
2008-6709
2008-6687
2016-10-01
7
4
175
184
42049
MicroRNAs and their Role in the Pathogenesis of Cervical Cancer
Ale Eba
1
Tasleem Raza
tasleem24@gmail.com
2
Saliha Rizvi
3
Farzana Mahdi
4
Department of Biochemistry, Era’s Lucknow Medical College and Hospital, Lucknow, India
Department of Biochemistry, Era’s Lucknow Medical College and Hospital, Lucknow, India
Department of Biochemistry, Era’s Lucknow Medical College and Hospital, Lucknow, India
Department of Biochemistry, Era’s Lucknow Medical College and Hospital, Lucknow, India
MicroRNAs are tiny, 18-25 nucleotides in length, non-coding RNA molecules preserved throughout evolution. These molecules primarily control gene expression at the post-transcriptional and transcriptional levels. MicroRNAs control target gene expression by a phenomenon known as RNA interference. RNA interference based therapeutics that utilize target gene silencing/degradation by specific microRNAs have potentially enormous advantages over traditional methodologies to treat diseases such as cancers with wide-ranging applicability, precision, and therapeutic selectivity, with decreased adverse side effects. If microRNA profiles can accurately predict malignancies, this technology may be exploited as a tool to surmount diagnostic challenges. This review highlights the successful use of RNA interference inducers against different type of cancers, thereby paving the way for specific therapeutic medicines. Studies have shown the association of microRNA dysregulation with diseases such as cancer. MicroRNAs can function as oncogenes as well as tumor suppressors. Thus, microRNA expression profiles can be used to determine prognosis, predict treatment efficiency and response to drug therapy, as well as patient susceptibility to cancer and metastasis. In addition, they may offer new candidate targets to be exploited for both prognostic and therapeutic strategies in patients with cervical cancer.
https://mejc.sums.ac.ir/article_42049_769c6b6e34a2288b6ae05b3cc946bf90.pdf
eng
Shiraz University of Medical Sciences
Middle East Journal of Cancer
2008-6709
2008-6687
2016-10-01
7
4
185
192
42050
FXYD3 and TNFα mRNA Expression in Laryngeal Squamous Cell Carcinoma and their Correlation with Clinicopathologic Parameters
Somayeh Dadras
1
Mahboobeh Razmkhah
mrazmkhah2@gmail.com
2
Bijan Khademi
khademib@yahoo.com
3
Mehdi Ansari
4
Ahmad Hosseini
5
Abbas Ghaderi
ghaderia@sums.ac.ir
6
Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran
Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran
Department of Otorhinolaryngology, Shiraz University of Medical Sciences, Shiraz, Iran
Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran
Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran
Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran
Background: Because of its effect on speech and swallowing, laryngeal squamous cell carcinoma is a devastating disease which has been shown to have a poor survival rate. Abundant research is being carried out in search of novel biomarkers that can aid the process of diagnosis and treatment of this disease. FXYD3, a modulator of Na/K-ATPase, is presented as a biomarker in some cancers. FXYD3 expression has been shown to be effected reversely by tumor necrosis factor alpha. Tumor necrosis factor alpha is a pro-inflammatory cytokine proposed to play an important role in tumor promotion and progression. In our study we examined FXYD3 and tumor necrosis factor alpha mRNA expressions, their correlation with each other and with clinicopathologic parameters in tumor tissues and lymph nodes.Methods: We assessed 75 tissue samples and 30 lymph node samples of laryngeal squamous cell carcinoma patients and compared them to 9 adjacent normal tissue samples by quantitative real-time polymerase chain reaction.Results: FXYD3 mRNA expression showed no significant difference among different tissues. We observed significantly lower tumor necrosis factor alpha mRNA expression in laryngeal tumor tissues compared to adjacent normal tissues. FXYD3 showed significant correlations with node metastasis (N factor), differentiation grade, and regional metastasis in lymph nodes. FXYD3 and tumor necrosis factor alpha mRNA levels significantly correlated in tumor and normal tissues.Conclusion: FXYD3 might be involved in the dedifferentiation and metastasis process of laryngeal squamous cell carcinoma. This biomarker has contributed to the aggressiveness and progression of the tumor. Verification of the observed results will need evaluation in a larger group of patients.
https://mejc.sums.ac.ir/article_42050_80d69912e37adcd86624606175476120.pdf
eng
Shiraz University of Medical Sciences
Middle East Journal of Cancer
2008-6709
2008-6687
2016-10-01
7
4
193
197
42051
Evaluation of Voice Parameters in People with Head and Neck Cancers: An Investigational Study
Thomas Zacharia
thomasaslp@gmail.com
1
Suresh Rao
sureshrao751964@gmail.com
2
Sanath Hegde
3
Preema D'souza
4
Judith James
judithjames91@gmail.com
5
Manjeshwar Baliga
msbaliga@gmail.com
6
Speech Language Pathologist, Radiation Oncology Department, Mangalore Institute of Oncology, Pumpwell, Mangalore, India
Radiation Oncology Department, Mangalore Institute of Oncology, Pumpwell, Mangalore, Karnataka, India
Radiation Oncology Department, Mangalore Institute of Oncology, Pumpwell, Mangalore, Karnataka, India
Speech Language Pathologist, Radiation Oncology Department, Mangalore Institute of Oncology, Pumpwell, Mangalore, India
Speech Language Pathologist, Radiation Oncology Department, Mangalore Institute of Oncology, Pumpwell, Mangalore, India
Radiation Oncology Department, Mangalore Institute of Oncology, Pumpwell, Mangalore, Karnataka, India
Background: A Head and Neck (H&N) cancer severely affect the voice and compromises the patient’s vocal independence. The present study proposed to investigate the difference in the three vital components of voice the pitch, jitter and shimmer in H&N cancer patients and compared it with age matched healthy volunteers.Methods: The voice parameters were ascertained in the freshly diagnosed H&N cancer patients and controls using the voice analysis software PRAAT and Dynamic Unidirectional AUD-59 XLR microphone in a sound proof voice recording laboratoryResults: The result indicates that a considerable change in the three voice indices, the pitch, jitter and shimmer were observed. On a gender perspective it was observed that the changes in all the three indices were significant for men (p < 0.015 to 0.0001), while it was significant in women (p = 0.0001) only for pitch.Conclusion: The results suggest that all individuals with any form of head and neck cancer will have some amount of voice problems even before the initiation of the cancer treatments and that the voice assessment is a vital aspect to be considered before initiation of the treatment.
https://mejc.sums.ac.ir/article_42051_b5d9eac7ccc04e26831e0d76b0a35775.pdf
eng
Shiraz University of Medical Sciences
Middle East Journal of Cancer
2008-6709
2008-6687
2016-10-01
7
4
199
202
42054
Epidemiology of Malignant Melanoma over a Thirty-two Year Period (1981-2013) in Southern Iran
Farhad Handjani
hanjanif@yahoo.com
1
Nasrin Saki
nasrinsa85@yahoo.com
2
Amin Parhizgar
sakina@sums.ac.ir
3
Sina Kardeh
sina.xix@gmail.com
4
Shima Rafiee
shima.rafiee1992@yahoo.com
5
Laleh Yaghutian Nezhad
6
Bahareh Kardeh
spring.13.bk@gmail.com
7
Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
Background:Malignant melanoma, one of the most deadly skin cancers, is a skin tumor that arises from the epidermal melanocytes. The aim of this study is to evaluate the demographic and clinical data of malignant melanoma patients in a referral dermatology center in the south of Iran.
Method: In this retrospective study, we have reviewed files of 116 patients diagnosed with malignant melanoma at hospitals affiliated with Shiraz University of Medical Sciences, Shiraz, Iran from March 1981 to March 2013.
Results: There was a total 116 malignant melanoma patients (79 male and 37 female) with the mean age of 54.7 (SD=13.9) years old for men and 51.7 (SD=12.4) years old for women. The male to female ratio of malignant melanoma was approximately two, as was the male to female mortality ratio. The most common clinical form was acral lentiginous melanoma. We have identified the most common site to be the sole of the foot. Malignant melanoma mostly presented as a mass and it was most common in farmers.
Conclusion: The national health system should improve the quality and quantity of cancer registry offices so that better and more complete data can be collected for further research and possible implementation of preventive measures with respect to this cancer.
https://mejc.sums.ac.ir/article_42054_b6f1c67904e78a72a9ac7d9c5a1d7846.pdf
Epidemiology
Skin
Melanoma
Iran
eng
Shiraz University of Medical Sciences
Middle East Journal of Cancer
2008-6709
2008-6687
2016-10-01
7
4
203
207
42055
Evaluation of the Methylation Status of the MEIS1 Promoter Gene in Colorectal Cancer
Narjes Soltani
mehraban9090@yahoo.com
1
Ehsan Ghayoor Karimiani
ehsan.gh@manchester.ac.uk
2
Mohammadreza Farzanehfar
farzanehfm@mums.ac.ir
3
Baratali Mashkani
mashkaniba@mums.ac.ir
4
Amirhossein Jafarian
jafarianah@mums.ac.ir
5
Hami Ashraf
mrhami_ashraf@yahoo.com
6
Arash Akhavan Rezyat
akhavanra901@mums.ac.ir
7
Mohammad Soukhtanloo
soukhtanloom@mums.ac.ir
8
Cancer Molecular Pathology Research Center, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Hope Genetic Polyclinic, Mashhad, Iran
Department of Internal Medicine, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Department of Medical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Cancer Molecular Pathology Research Center, Department of Pathology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Razavi Cancer Research Center, Research and Education Department, Razavi Hospital, Mashhad, Iran
Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Department of Medical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Background: Colorectal cancer, the third most common type of cancer is a major cause of mortality worldwide. If colorectal cancer is detected at the early stages, the 5-year survival rate is 90%. MEIS1 homeobox gene is implicated in numerous solid tumors and hematological malignancies. Therefore, the present study aims to investigate the methylation status of the MEIS1 gene in colorectal cancer.Methods: We used real-time quantitative methylation-specific PCR to detect MEIS1 promoter methylation in 42 colorectal cancer tissues and 42 normal colorectal tissues.Results: Methylation was observed only in the positive control samples - CG Genome Universal Unmethylated DNA and CG Genome Universal Methylated DNA. There was no change observed in MEIS1 promoter methylation status in 42 patients.Conclusion: The results of the current study indicated that the MEIS1 gene promoter was not methylated in the cases. Gene expression study confirmed the unmethylated status of the MEIS1 gene in the colorectal cancer process among the studied population.
https://mejc.sums.ac.ir/article_42055_091cbf8ef7ca281fda73305bc7fa6f70.pdf
eng
Shiraz University of Medical Sciences
Middle East Journal of Cancer
2008-6709
2008-6687
2016-10-01
7
4
209
213
42048
Cribriform-Morular Variant of a Papillary Carcinoma: A Case Report
Kanapilly Magdalene
magdalenekf@gmail.com
1
Narayanan Navya
2
Pathology department, Sree Narayana Institute of Medical Sciences, Chalaka, Kochi Kerala, India
Pathology department, Sree Narayana Institute of Medical Sciences, Chalaka, Kochi Kerala, India
Worldwide, thyroid cancers are the most common type of endocrine-related cancers. Papillary carcinoma accounts for the most frequent type of thyroid malignancy. A rare variant of papillary carcinoma of the thyroid is the cribriform-morular variant. We report a case of solitary, cribriform-morularvariant of papillary carcinoma in a 55-year-old lady. It is important to identify this variant because of a better prognosis compared to the other aggressive variants and poorly differentiated thyroid cancers. Multifocal cribriform-morular variant of papillary carcinoma may be the first manifestation of familial adenomatous polyposis.
https://mejc.sums.ac.ir/article_42048_fc614f4a8eae2d6987011b17fcab338e.pdf
eng
Shiraz University of Medical Sciences
Middle East Journal of Cancer
2008-6709
2008-6687
2016-10-01
7
4
215
219
42052
Bilateral Synchronous Male Breast Cancer in Iran: A Case Report
Vahid Zangouri
zangouri.vahid1390@gmail.com
1
Mohammad Yasin Karami
karamiy@sums.ac.ir
2
Maral Mokhtari
maral_mokhtari@yahoo.com
3
Majid Akrami
akramimd@yahoo.com
4
Sedighe Tahmasebi
5
Abdolrasoul Talei
taleiar@gmail.com
6
Mehrnoosh Maalhagh
7
Breast Diseases Research Center, Department of Surgery, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Student Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Breast Diseases Research Center, Department of Surgery, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Breast Diseases Research Center, Department of Surgery, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Breast Diseases Research Center, Department of Surgery, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Student Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Bilateral synchronous male breast cancer is very rare. A 63-year-old male presented with rapidly progressive enlarging bilateral breast masses without ulceration and bloody nipple discharge. Synchronous bilateral breast cancer was diagnosed by fine needle aspiration cytology. Pathology study revealed grade 2 invasive ductal carcinoma in both breasts. He underwent a bilateral modified radical mastectomy followed by chemotherapy and hormone therapy. The importance of this case report is to create increased attention to the fact that, although rare, breast cancer can occur in males. Early presentation and compliance with treatment modality provide a better outcome.
https://mejc.sums.ac.ir/article_42052_211dfaeaf7c457c17cea6b645eccffd2.pdf
eng
Shiraz University of Medical Sciences
Middle East Journal of Cancer
2008-6709
2008-6687
2016-10-01
7
4
221
223
42053
Limbic Encephalitis Driven by a Pleural Mesothelioma: A Paraneoplastic Complication
Jacob Day
jacobday@doctors.org.uk
1
Adam Zeman
a.zeman@exeter.ac.uk
2
Royal Devon and Exeter NHS Foundation Trust, Exeter, Devon, UK
University of Exeter Medical School, Exeter, Devon, UK
Paraneoplastic neurological syndromes have only been described with pleural mesothelioma in five cases. We have described a 72-year-old man who developed anterograde amnesia 27 months after diagnosis of epithelioid pleural mesothelioma. Investigations revealed a limbic encephalitis with no alternative causes identified. Limbic encephalitis is a classical paraneoplastic syndrome and presentation within five years of a cancer with no other causes identified is sufficient to diagnose a paraneoplastic etiology. This is the first case of isolated paraneoplastic limbic encephalitis driven by a pleural mesothelioma.
https://mejc.sums.ac.ir/article_42053_f73a83592ce0de9ee8b050b90b65036b.pdf
eng
Shiraz University of Medical Sciences
Middle East Journal of Cancer
2008-6709
2008-6687
2016-10-01
7
4
225
228
42056
Hodgkin's Lymphoma with Cutaneous Involvement
Ahmad Ameri
aham47@yahoo.com
1
Ainaz Sourati
ainazsourati@yahoo.com
2
Department of Radiation Oncology, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Department of Radiation Oncology, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Cutaneous Hodgkin’s lymphoma is a rare disease (0.5% to 3.4%) which tends to be in the setting of an advanced disease and has a poor prognosis. Treatment of patients with cutaneous involvement of Hodgkin’s lymphoma is according to dissemination of disease (systemic or localized therapy). The majority of data in this context are based on individual case reports or literature reviews. We have reported a case of Hodgkin’s lymphoma that relapsed with isolated cutaneous involvement two years after completion of his first treatment. Our case had no response to systemic chemotherapy but obtained a complete remission to radiation therapy and had longterm disease-free survival. Radiotherapy might be considered a good salvage treatment in patients with cutaneous Hodgkin’s lymphoma with long-term disease-free survival.
https://mejc.sums.ac.ir/article_42056_5fcaa0608b16199a30dc13fc7c0efe9e.pdf
eng
Shiraz University of Medical Sciences
Middle East Journal of Cancer
2008-6709
2008-6687
2016-10-01
7
4
229
233
42057
Mature Cystic Teratoma of the Uterine Surface and Ovary with Adenocarcinoma of the Endometrium: An Unusual Case Scenario and Literature Review
Kangana Sengar
drksengar@gmail.com
1
Monal Trisal
monaltrisal@gmail.com
2
Sanjay Deb
sanjaydeb@hotmail.com
3
Ramesh Dawar
rameshdawar@hotmail.com
4
Department of Pathology and Transfusion Medicine, Dharamshila Hospital and Research Centre, New Delhi, India
Department of Pathology and Transfusion Medicine, Dharamshila Hospital and Research Centre, New Delhi, India
Department of Pathology and Transfusion Medicine, Dharamshila Hospital and Research Centre, New Delhi, India
Department of Pathology and Transfusion Medicine, Dharamshila Hospital and Research Centre, New Delhi, India
Teratomas that occur in the uterus are exceedingly rare. To the best of our knowledge there are only 22 cases of mature and immature teratomas of the uterus and cervix thus far reported in the literature. We report an unusual case of mature cystic teratoma of the uterine surface with well-differentiated adenocarcinoma of the endometrium and uterine leiomyoma along with a mature cystic teratoma of the right ovary.
https://mejc.sums.ac.ir/article_42057_b3108eaad2b6ebf6b90efa7463341d9f.pdf
eng
Shiraz University of Medical Sciences
Middle East Journal of Cancer
2008-6709
2008-6687
2016-10-01
7
4
234
234
42047
Calendar of Events
Calendar of Events
https://mejc.sums.ac.ir/article_42047_1e6267046835eb717ffd7d3b9f77ded0.pdf