eng
Shiraz University of Medical Sciences
Middle East Journal of Cancer
2008-6709
2008-6687
2010-04-01
1
2
59
63
41914
Safe and Judicious Use of Advanced Radiotherapy Techniques and Equipment: A Medical Physicist's Perspective on Recent Accident Reports
Mohammad Amin Mosleh-Shirazi
amosleh@sums.ac.ir
1
Physics Unit, Department of Radiotherapy and Oncology, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
https://mejc.sums.ac.ir/article_41914_3aed31a4db1d016345b6b75d205f7cae.pdf
eng
Shiraz University of Medical Sciences
Middle East Journal of Cancer
2008-6709
2008-6687
2010-04-01
1
2
65
68
41913
Serum HER2 Level in Epithelial Ovarian Cancer
Zahra Mojtahedi
mojtahediz@sums.ac.ir
1
Sharareh Solati Dalaki
2
Alamtaj Samsami Dehaghani
3
Minoo Robati
minoorobati@yahoo.com
4
Ahmad Monabati
ahmad_monabati@yahoo.com
5
Mohammad Javad Fattahi
6
Abbas Ghaderi
ghaderia@sums.ac.ir
7
Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran
Department of Obstetrics and Gynecology, Shiraz University of Medical Sciences, Shiraz, Iran
Department of Obstetrics and Gynecology, Shiraz University of Medical Sciences, Shiraz, Iran
Department of Obstetrics and Gynecology, Shiraz University of Medical Sciences, Shiraz, Iran
Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran
Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran
Department of Immunology, Shiraz University of Medical Sciences, Shiraz, Iran
Introduction: The proto-oncogene HER2 plays a key role in the control of cellular proliferation. Its overexpression has been reported to be associated with a poor prognosis in cancer, particularly in breast cancer.Materials and Methods: In the present study, serum HER2 levels were investigated in patients diagnosed with epithelial ovarian cancer. Serum HER2 levels were detected by an ELISA commercial kit in 51 patients and 33 healthy individuals.Results: The mean serum HER2 level was found to be significantly higher in patients than healthy controls (P=0.005). In 29% of patients, serum HER2 levels were higher than the cut-off value. HER2 serum level was not associated with tumor stage at diagnosis.Conclusion: Elevation of HER2 in a high proportion of patients with epithelial ovarian cancer further strengthens the importance of this molecule in the pathogenesis of ovarian cancer.
https://mejc.sums.ac.ir/article_41913_8ee4ecb4c217c81ed2130f20b410bf90.pdf
eng
Shiraz University of Medical Sciences
Middle East Journal of Cancer
2008-6709
2008-6687
2010-04-01
1
2
69
76
41916
Effect of Oral Zinc Sulphate in Prevention of Radiation Induced Oropharyngeal Mucositis During and After Radiotherapy in Patients with Head and Neck Cancers
Ahmad Mosalaei
mosalaa@gmail.com
1
Hamid Nasrolahi
nasrolahi.hamid@gmail.com
2
Amin Shafizad
shafizad1356@yahoo.com
3
Niloofar Ahmadloo
ahmadloon@gmail.com
4
Mansour Ansari
ansarim_1999@yahoo.com
5
Mohammad Amin Mosleh-Shirazi
amosleh@sums.ac.ir
6
Shapour Omidvari
omidvari@sums.ac.ir
7
Mohammad Mohammadianpanah
mohpanah@gmail.com
8
Department of Radiation Oncology, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
Department of Radiation Oncology, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
Department of Radiation Oncology, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
Department of Radiation Oncology, Nemazee Hospital, Shiraz University of Medical
Sciences, Shiraz, Iran
Department of Radiation Oncology, Nemazee Hospital, Shiraz University of Medical
Sciences, Shiraz, Iran
Department of Radiation Oncology, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
Department of Radiation Oncology, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
Department of Radiation Oncology, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
Introduction:Mucositis is a disturbing side effect of radiotherapy treatment for head and neck cancer. To date, no effective modality for its prophylaxis and treatment has been found. We performed this study to evaluate the efficacy of oral zinc sulphate in delaying the onset of oral and pharyngeal mucositis and decreasing their severity.Materials and Methods: A total of 58 patients who were treated for head and neck squamous cell carcinoma with radiotherapy or chemoradiotherapy were randomly assigned to receive oral zinc sulphate (220 mg) or an oral placebo 3 times a day during their radiotherapy course. Total radiation dose was 6000 cGy to 7000 cGy by conventional radiotherapy. Seventy nine percent of the patients also received concurrent chemotherapy. Oral and pharyngeal mucositis were scored according to an RTOG protocol.Results: Time to onset of mucositis did not vary between the two groups. However, oral mucositis scores were less severe in the zinc group in weeks 4 to 6. The difference was statistically significant and the P values for weeks 4, 5 and 6 were 0.02, 0.007, and 0.012, respectively. Treatment interruptions in both groups were the same (four cases each) and all were due to dysphagia (pharyngeal mucositis).Conclusion: Our results suggest that zinc is effective in reducing the severity of oral mucositis but not pharyngeal mucositis. Treatment interruptions were more frequently caused by pharyngeal mucositis which presented as dysphagia, rather than oral pain that was a manifestation of oral mucositis.
https://mejc.sums.ac.ir/article_41916_ffb5386da0b7f96de57d3c26855a8da0.pdf
eng
Shiraz University of Medical Sciences
Middle East Journal of Cancer
2008-6709
2008-6687
2010-04-01
1
2
77
81
41917
Serum Level of Galectin-3 in Patients with Oral Squamous Cell Carcinoma
Azadeh Andisheh Tadbir
andisheh202003@yahoo.com
1
Mohmmad Javad Fattahi
2
Bijan Khademi
khademib@yahoo.com
3
Sara Pourshahidi
andisheh@sums.ac.ir
4
Hooman Ebrahimi
5
Yasaman Sardari
6
Zahra Fattah
7
Department of Oral Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran
Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran
Department of Otolaryngology, Shiraz University of Medical Sciences, Shiraz, Iran
Department of Oral Medicine, School of Dentistry, Shiraz University of Medical Sciences,Shiraz, Iran
Department of Oral Medicine, School of Dentistry, Shiraz University of Medical Sciences,Shiraz, Iran
Department of Oral Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran
School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran
Introduction: Galectin-3, a member of the family of β-galactoside-binding animal lectins, has been implicated in tumor invasion and metastasis.Materials and Methods: Using an ELISAkit, we assessed the circulating levels of galectin-3 in sera from 40 oral squamous cell carcinoma (OSCC) patients and from 43 healthy controls.Results: Serum galectin-3 levels in OSCC patients were significantly higher (5.1±2.5 ng/ml) when compared with healthy controls (2.6±3.07 ng/ml, P<0.0005). There was no apparent correlation between serum galectin-3 concentration and clinico-pathological features such as stage, tumor size, nodal status, distant metastasis and histological grade.Conclusion: This result suggests that, in addition to other tests, measurement of serum galectin-3 concentrations can be utilized as an adjuvant test for establishing a diagnosis of OSCC.
https://mejc.sums.ac.ir/article_41917_4cb1dc57a99850907584df76c3260d90.pdf
eng
Shiraz University of Medical Sciences
Middle East Journal of Cancer
2008-6709
2008-6687
2010-04-01
1
2
83
88
41918
Evaluation of Contributive Factors on Recurrence of Intracranial Meningioma
Majid Reza Farrokhi
farokhim@sums.ac.ir
1
Zeinab Ansari
farrokhi_drmr@yahoo.com
2
Shiraz Neurosciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Shiraz Neurosciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Background: Meningiomas are common benign tumors of the central nervous system. Patients with meningiomas achieve postoperative optimal functional recovery, but there is a probability of tumor recurrence months or years after surgical resection. This study aims to evaluate the prevalence of recurrent meningioma and the correlation between tumor recurrence and certain factors.Materials and Methods: We performed a retrospective descriptive-analytical study of patients with meningiomas who underwent surgical treatment in hospitals affiliated with Shiraz University of Medical Sciences during a 20-year period (1988 to 2008). Factors including sex, age, bone changes, peritumoral edema, histological subtypes, tumor size, shape, location and resection degree, and recurrence time were evaluated in each patient.Results: The recurrence rate of intracranial meningioma in a total of 644 patients included in the study was 10%. Statistical analysis of data showed a correlation between edema, bone changes, tumor size and shape, and histological subtypes. No relationship was found between age, sex and tumor location. This study has shown a statistical correlation between radiotherapy and a reduced probability of tumor recurrence or growth after surgical resection.Conclusion: Although the majority of meningiomas are benign, they can have malignant presentations. Recurrence occurs after a shorter period of time in patients with malignant and atypical meningiomas than in patients with benign meningiomas. Edema, bone changes, large size, special tumor shape and malignant histological subtypes are important prognostic factors that predict the probability of tumor recurrence or growth. Findings show a statistical correlation between the degree of tumor resection and its recurrence. This study recommends a more complete tumor resection along with adjuvant therapy and closer follow-up to decrease the risk of tumor recurrence.This article is based on a study first reported in Tehran University Medical Journal; Vol. 64, No. 12, March 2007: 91-96 (in Persian).
https://mejc.sums.ac.ir/article_41918_2de13ac13f296c1d8662bc64a2fc17b5.pdf
eng
Shiraz University of Medical Sciences
Middle East Journal of Cancer
2008-6709
2008-6687
2010-04-01
1
2
89
94
41911
Middle East Special Report
Disclosure of Cancer Diagnosis: Pakistani Patients' Perspective
Masood Jawaid
masood@masoodjawaid.com
1
Beenish Qamar
2
Zubia Masood
3
Shaukat Jawaid
4
Surgical Unit, Civil Hospital, Karachi, Pakistan
Surgical Unit, Civil Hospital, Karachi, Pakistan
Surgical Unit, Civil Hospital, Karachi, Pakistan
Member of National Bioethics Committee, Government of Pakistan
Objective: To ascertain cancer patients' views regarding disclosure of diagnosis in the Pakistani population, anxiety levels after disclosure of the diagnosis, interest in knowing all the treatment options and desire to inform their families.Patients and Methods: In this cross-sectional study, 147 cancer patients from different hospitals in Pakistan were asked questions to determine their opinions regarding whether the diagnosis of cancer should be disclosed to patients and their relatives or not. Anxiety after diagnosis disclosure and who should disclose this information were also asked. Patients were also asked about their views regarding whether their families should be informed about the cancer diagnosis without patient's prior consent.Results:Atotal of 147 cancer patients completed the questionnaire. Of these, 112 (76.2%) wanted to know about their cancer diagnosis while only 28 (19.0%) patients refused. Anxiety levels were increased in 59 (40.1%) patients, remained the same in 61 (41.5%) and decreased in 27 (18.4%). One hundred and twenty three patients (83.7%), wanted to know the diagnosis from their physicians. Eighty-four (57.1%) patients were interested in all treatment options, while 102 (69.4%) patients wanted to be actively involved in decision making about their treatment. Only 37 (25.2%) patients answered affirmatively to the question which asked if their families were informed about the patient's disease without patient's prior knowledge, while 82 (55.8%) disagreed.Conclusion: The majority of cancer patients wanted disclosure of their disease by their doctor. The results of this study provide important implications for Pakistani doctors concerning the practice of diagnostic cancer disclosure to the patients.
https://mejc.sums.ac.ir/article_41911_0f98f5ffa74d26c6fbf96d03a74456b6.pdf
eng
Shiraz University of Medical Sciences
Middle East Journal of Cancer
2008-6709
2008-6687
2010-04-01
1
2
95
98
41912
Multicentric Astrocytoma Presenting with Supra- and Infratentorial Involvement: A Case Report
Farhad Emadi
borhanaaihaghighi@yahoo.com
1
Research Center for Traditional Medicine and History of Medicine and Department of Neurology, Shiraz University of Medical Sciences, Shiraz, Iran
This report describes the case of a 56 year-old man with a history of diplopia. His brain imaging showed multiple lesions with a metastatic appearance, however all investigations to determine the primary source of malignancy were negative. The patient underwent a brain biopsy, which was positive for anaplastic astrocytoma, a rare tumor that should be considered in the differential diagnosis of secondary brain tumors.
https://mejc.sums.ac.ir/article_41912_801c7c727aebbd3e00b6a38923c2ae51.pdf
eng
Shiraz University of Medical Sciences
Middle East Journal of Cancer
2008-6709
2008-6687
2010-04-01
1
2
99
102
41915
Retinoblastoma in Adolescence: Report of an Unusual Presentation
Morteza Mehdizadeh
eghtedaarim@gmail.com
1
Masoomeh Eghtedari
eghtedarim@gmail.com
2
Mohammad Reza Khalili
3
Poostchi Eye Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Poostchi Eye Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Poostchi Eye Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Herein, we report the clinical, pathologic and photographic findings of a 16 year-old girl who presented with gradual enlargement of a vascularized, hemorrhagic peripapillary mass that eventually led to vitreous hemorrhage and rubeosis iridis. Histopathological findings after enucleation were positive for retinoblastoma. The patient did not have any metastasis during her 20 months of follow up.
https://mejc.sums.ac.ir/article_41915_5865eea90c3a96af07b8bee04f4e2e1d.pdf