@article { author = {Andisheh Tadbir, Azadeh and Fattahi, Mohmmad Javad and Khademi, Bijan and Pourshahidi, Sara and Ebrahimi, Hooman and Sardari, Yasaman and Fattah, Zahra}, title = {Serum Level of Galectin-3 in Patients with Oral Squamous Cell Carcinoma}, journal = {Middle East Journal of Cancer}, volume = {1}, number = {2}, pages = {77-81}, year = {2010}, publisher = {Shiraz University of Medical Sciences}, issn = {2008-6709}, eissn = {2008-6687}, doi = {}, abstract = {Introduction: Galectin-3, a member of the family of β-galactoside-binding animal lectins, has been implicated in tumor invasion and metastasis.Materials and Methods: Using an ELISAkit, we assessed the circulating levels of galectin-3 in sera from 40 oral squamous cell carcinoma (OSCC) patients and from 43 healthy controls.Results: Serum galectin-3 levels in OSCC patients were significantly higher (5.1±2.5 ng/ml) when compared with healthy controls (2.6±3.07 ng/ml, P<0.0005). There was no apparent correlation between serum galectin-3 concentration and clinico-pathological features such as stage, tumor size, nodal status, distant metastasis and histological grade.Conclusion: This result suggests that, in addition to other tests, measurement of serum galectin-3 concentrations can be utilized as an adjuvant test for establishing a diagnosis of OSCC.}, keywords = {}, url = {https://mejc.sums.ac.ir/article_41917.html}, eprint = {https://mejc.sums.ac.ir/article_41917_4cb1dc57a99850907584df76c3260d90.pdf} }