@article { author = {Mosleh-Shirazi, Mohammad Amin}, title = {Safe and Judicious Use of Advanced Radiotherapy Techniques and Equipment: A Medical Physicist's Perspective on Recent Accident Reports}, journal = {Middle East Journal of Cancer}, volume = {1}, number = {2}, pages = {59-63}, year = {2010}, publisher = {Shiraz University of Medical Sciences}, issn = {2008-6709}, eissn = {2008-6687}, doi = {}, abstract = {}, keywords = {}, url = {https://mejc.sums.ac.ir/article_41914.html}, eprint = {https://mejc.sums.ac.ir/article_41914_3aed31a4db1d016345b6b75d205f7cae.pdf} } @article { author = {Mojtahedi, Zahra and Solati Dalaki, Sharareh and Samsami Dehaghani, Alamtaj and Robati, Minoo and Monabati, Ahmad and Fattahi, Mohammad Javad and Ghaderi, Abbas}, title = {Serum HER2 Level in Epithelial Ovarian Cancer}, journal = {Middle East Journal of Cancer}, volume = {1}, number = {2}, pages = {65-68}, year = {2010}, publisher = {Shiraz University of Medical Sciences}, issn = {2008-6709}, eissn = {2008-6687}, doi = {}, abstract = {Introduction: The proto-oncogene HER2 plays a key role in the control of cellular proliferation. Its overexpression has been reported to be associated with a poor prognosis in cancer, particularly in breast cancer.Materials and Methods: In the present study, serum HER2 levels were investigated in patients diagnosed with epithelial ovarian cancer. Serum HER2 levels were detected by an ELISA commercial kit in 51 patients and 33 healthy individuals.Results: The mean serum HER2 level was found to be significantly higher in patients than healthy controls (P=0.005). In 29% of patients, serum HER2 levels were higher than the cut-off value. HER2 serum level was not associated with tumor stage at diagnosis.Conclusion: Elevation of HER2 in a high proportion of patients with epithelial ovarian cancer further strengthens the importance of this molecule in the pathogenesis of ovarian cancer.}, keywords = {}, url = {https://mejc.sums.ac.ir/article_41913.html}, eprint = {https://mejc.sums.ac.ir/article_41913_8ee4ecb4c217c81ed2130f20b410bf90.pdf} } @article { author = {Mosalaei, Ahmad and Nasrolahi, Hamid and Shafizad, Amin and Ahmadloo, Niloofar and Ansari, Mansour and Mosleh-Shirazi, Mohammad Amin and Omidvari, Shapour and Mohammadianpanah, Mohammad}, title = {Effect of Oral Zinc Sulphate in Prevention of Radiation Induced Oropharyngeal Mucositis During and After Radiotherapy in Patients with Head and Neck Cancers}, journal = {Middle East Journal of Cancer}, volume = {1}, number = {2}, pages = {69-76}, year = {2010}, publisher = {Shiraz University of Medical Sciences}, issn = {2008-6709}, eissn = {2008-6687}, doi = {}, abstract = {Introduction:Mucositis is a disturbing side effect of radiotherapy treatment for head and neck cancer. To date, no effective modality for its prophylaxis and treatment has been found. We performed this study to evaluate the efficacy of oral zinc sulphate in delaying the onset of oral and pharyngeal mucositis and decreasing their severity.Materials and Methods: A total of 58 patients who were treated for head and neck squamous cell carcinoma with radiotherapy or chemoradiotherapy were randomly assigned to receive oral zinc sulphate (220 mg) or an oral placebo 3 times a day during their radiotherapy course. Total radiation dose was 6000 cGy to 7000 cGy by conventional radiotherapy. Seventy nine percent of the patients also received concurrent chemotherapy. Oral and pharyngeal mucositis were scored according to an RTOG protocol.Results: Time to onset of mucositis did not vary between the two groups. However, oral mucositis scores were less severe in the zinc group in weeks 4 to 6. The difference was statistically significant and the P values for weeks 4, 5 and 6 were 0.02, 0.007, and 0.012, respectively. Treatment interruptions in both groups were the same (four cases each) and all were due to dysphagia (pharyngeal mucositis).Conclusion: Our results suggest that zinc is effective in reducing the severity of oral mucositis but not pharyngeal mucositis. Treatment interruptions were more frequently caused by pharyngeal mucositis which presented as dysphagia, rather than oral pain that was a manifestation of oral mucositis.}, keywords = {}, url = {https://mejc.sums.ac.ir/article_41916.html}, eprint = {https://mejc.sums.ac.ir/article_41916_ffb5386da0b7f96de57d3c26855a8da0.pdf} } @article { author = {Andisheh Tadbir, Azadeh and Fattahi, Mohmmad Javad and Khademi, Bijan and Pourshahidi, Sara and Ebrahimi, Hooman and Sardari, Yasaman and Fattah, Zahra}, title = {Serum Level of Galectin-3 in Patients with Oral Squamous Cell Carcinoma}, journal = {Middle East Journal of Cancer}, volume = {1}, number = {2}, pages = {77-81}, year = {2010}, publisher = {Shiraz University of Medical Sciences}, issn = {2008-6709}, eissn = {2008-6687}, doi = {}, abstract = {Introduction: Galectin-3, a member of the family of β-galactoside-binding animal lectins, has been implicated in tumor invasion and metastasis.Materials and Methods: Using an ELISAkit, we assessed the circulating levels of galectin-3 in sera from 40 oral squamous cell carcinoma (OSCC) patients and from 43 healthy controls.Results: Serum galectin-3 levels in OSCC patients were significantly higher (5.1±2.5 ng/ml) when compared with healthy controls (2.6±3.07 ng/ml, P<0.0005). There was no apparent correlation between serum galectin-3 concentration and clinico-pathological features such as stage, tumor size, nodal status, distant metastasis and histological grade.Conclusion: This result suggests that, in addition to other tests, measurement of serum galectin-3 concentrations can be utilized as an adjuvant test for establishing a diagnosis of OSCC.}, keywords = {}, url = {https://mejc.sums.ac.ir/article_41917.html}, eprint = {https://mejc.sums.ac.ir/article_41917_4cb1dc57a99850907584df76c3260d90.pdf} } @article { author = {Farrokhi, Majid Reza and Ansari, Zeinab}, title = {Evaluation of Contributive Factors on Recurrence of Intracranial Meningioma}, journal = {Middle East Journal of Cancer}, volume = {1}, number = {2}, pages = {83-88}, year = {2010}, publisher = {Shiraz University of Medical Sciences}, issn = {2008-6709}, eissn = {2008-6687}, doi = {}, abstract = {Background: Meningiomas are common benign tumors of the central nervous system. Patients with meningiomas achieve postoperative optimal functional recovery, but there is a probability of tumor recurrence months or years after surgical resection. This study aims to evaluate the prevalence of recurrent meningioma and the correlation between tumor recurrence and certain factors.Materials and Methods: We performed a retrospective descriptive-analytical study of patients with meningiomas who underwent surgical treatment in hospitals affiliated with Shiraz University of Medical Sciences during a 20-year period (1988 to 2008). Factors including sex, age, bone changes, peritumoral edema, histological subtypes, tumor size, shape, location and resection degree, and recurrence time were evaluated in each patient.Results: The recurrence rate of intracranial meningioma in a total of 644 patients included in the study was 10%. Statistical analysis of data showed a correlation between edema, bone changes, tumor size and shape, and histological subtypes. No relationship was found between age, sex and tumor location. This study has shown a statistical correlation between radiotherapy and a reduced probability of tumor recurrence or growth after surgical resection.Conclusion: Although the majority of meningiomas are benign, they can have malignant presentations. Recurrence occurs after a shorter period of time in patients with malignant and atypical meningiomas than in patients with benign meningiomas. Edema, bone changes, large size, special tumor shape and malignant histological subtypes are important prognostic factors that predict the probability of tumor recurrence or growth. Findings show a statistical correlation between the degree of tumor resection and its recurrence. This study recommends a more complete tumor resection along with adjuvant therapy and closer follow-up to decrease the risk of tumor recurrence.This article is based on a study first reported in Tehran University Medical Journal; Vol. 64, No. 12, March 2007: 91-96 (in Persian).}, keywords = {}, url = {https://mejc.sums.ac.ir/article_41918.html}, eprint = {https://mejc.sums.ac.ir/article_41918_2de13ac13f296c1d8662bc64a2fc17b5.pdf} } @article { author = {Jawaid, Masood and Qamar, Beenish and Masood, Zubia and Jawaid, Shaukat}, title = {Disclosure of Cancer Diagnosis: Pakistani Patients' Perspective}, journal = {Middle East Journal of Cancer}, volume = {1}, number = {2}, pages = {89-94}, year = {2010}, publisher = {Shiraz University of Medical Sciences}, issn = {2008-6709}, eissn = {2008-6687}, doi = {}, abstract = {Objective: To ascertain cancer patients' views regarding disclosure of diagnosis in the Pakistani population, anxiety levels after disclosure of the diagnosis, interest in knowing all the treatment options and desire to inform their families.Patients and Methods: In this cross-sectional study, 147 cancer patients from different hospitals in Pakistan were asked questions to determine their opinions regarding whether the diagnosis of cancer should be disclosed to patients and their relatives or not. Anxiety after diagnosis disclosure and who should disclose this information were also asked. Patients were also asked about their views regarding whether their families should be informed about the cancer diagnosis without patient's prior consent.Results:Atotal of 147 cancer patients completed the questionnaire. Of these, 112 (76.2%) wanted to know about their cancer diagnosis while only 28 (19.0%) patients refused. Anxiety levels were increased in 59 (40.1%) patients, remained the same in 61 (41.5%) and decreased in 27 (18.4%). One hundred and twenty three patients (83.7%), wanted to know the diagnosis from their physicians. Eighty-four (57.1%) patients were interested in all treatment options, while 102 (69.4%) patients wanted to be actively involved in decision making about their treatment. Only 37 (25.2%) patients answered affirmatively to the question which asked if their families were informed about the patient's disease without patient's prior knowledge, while 82 (55.8%) disagreed.Conclusion: The majority of cancer patients wanted disclosure of their disease by their doctor. The results of this study provide important implications for Pakistani doctors concerning the practice of diagnostic cancer disclosure to the patients.}, keywords = {}, url = {https://mejc.sums.ac.ir/article_41911.html}, eprint = {https://mejc.sums.ac.ir/article_41911_0f98f5ffa74d26c6fbf96d03a74456b6.pdf} } @article { author = {Emadi, Farhad}, title = {Multicentric Astrocytoma Presenting with Supra- and Infratentorial Involvement: A Case Report}, journal = {Middle East Journal of Cancer}, volume = {1}, number = {2}, pages = {95-98}, year = {2010}, publisher = {Shiraz University of Medical Sciences}, issn = {2008-6709}, eissn = {2008-6687}, doi = {}, abstract = {This report describes the case of a 56 year-old man with a history of diplopia. His brain imaging showed multiple lesions with a metastatic appearance, however all investigations to determine the primary source of malignancy were negative. The patient underwent a brain biopsy, which was positive for anaplastic astrocytoma, a rare tumor that should be considered in the differential diagnosis of secondary brain tumors.}, keywords = {}, url = {https://mejc.sums.ac.ir/article_41912.html}, eprint = {https://mejc.sums.ac.ir/article_41912_801c7c727aebbd3e00b6a38923c2ae51.pdf} } @article { author = {Mehdizadeh, Morteza and Eghtedari, Masoomeh and Khalili, Mohammad Reza}, title = {Retinoblastoma in Adolescence: Report of an Unusual Presentation}, journal = {Middle East Journal of Cancer}, volume = {1}, number = {2}, pages = {99-102}, year = {2010}, publisher = {Shiraz University of Medical Sciences}, issn = {2008-6709}, eissn = {2008-6687}, doi = {}, abstract = {Herein, we report the clinical, pathologic and photographic findings of a 16 year-old girl who presented with gradual enlargement of a vascularized, hemorrhagic peripapillary mass that eventually led to vitreous hemorrhage and rubeosis iridis. Histopathological findings after enucleation were positive for retinoblastoma. The patient did not have any metastasis during her 20 months of follow up.}, keywords = {}, url = {https://mejc.sums.ac.ir/article_41915.html}, eprint = {https://mejc.sums.ac.ir/article_41915_5865eea90c3a96af07b8bee04f4e2e1d.pdf} }