The Association of Vitamin D Deficiency with Colorectal Cancer: A Wake-up Call for Physicians and Health Authorities
Salman
Guraya
The College of Medicine, Taibah University, Almadinah Almunawwarah, Saudi Arabia
author
text
article
2017
eng
Although there is evidence that vitamin D deficiency leads to the development of several cancers, including colorectal cancer, research has shown gaps in establishing a relationship between hypovitaminosis D and the incidence of colorectal cancer. There are controversial reports and inadequate scientific evidence about the role of age and race-specific dosage of vitamin D supplementation for chemoprevention. This editorial sheds light on the current evidence on the association of vitamin D deficiency and colorectal cancer, the role of vitamin D supplementation, and the future action plans to establish the needs analysis and goal setting about this area of research.
Middle East Journal of Cancer
Shiraz University of Medical Sciences
2008-6709
8
v.
2
no.
2017
65
68
https://mejc.sums.ac.ir/article_42067_5b166748d9c11bef9fcfc00f4f488a74.pdf
Relationship between MMP-11 Expression in Invasive Ductal Breast Carcinoma with its Clinicopathologic Parameters
Farshad
Naghshvar
Department of Pathology, School of Medicine, Mazandaran University of Medical
Sciences, Sari, Iran
author
Zhila
Torabizadeh
Gut and Liver Research Center, Mazandaran University of Medical Sciences, Imam
Hospital, Sari, Iran
author
Jamshid
Yazdani Charati
Department of Biostatistics, School of Public Health, Mazandaran University of Medical
Sciences, Sari, Iran
author
Mohammad
Akbarnezhad
Department of Pathology, School of Medicine, Mazandaran University of Medical
Sciences, Imam Hospital, Sari, Iran
author
text
article
2017
eng
Background: Breast cancer is one of the most common cancers in the world, particularly in Iran. There are many genomic and molecular factors that cause the occurrence of breast cancer. Many markers are associated with tumor invasiveness. Matrix metalloproteinase includes a family of zinc-dependent endopeptidases that degrade various components of the extracellular matrix and basement membrane. Matrix metalloproteinase expressions increase in thyroid, colorectal, head and neck squamous cell carcinoma, lung, and ovarian cancers. It is correlated with tumor angiogenesis, invasion, and metastasis. Matrix metalloproteinase 11 is a member of the stromelysin subclass of the matrix metalloproteinase family. This enzyme is secreted to become a potentially active form against other matrix metalloproteinases. Contradictory results exist regarding the correlation between matrix metalloproteinase 11 expression and clinicopathologic parameters in breast cancer.Methods: This case-control study examined 80 invasive ductal carcinoma of the breast and 80 adjacent nonneoplastic breast tissue paraffin blocks to identify the relationship between matrix metalloproteinase 11 expression and clinicopathologic parameters such as age, tumor size, microscopic grade, perineural and vascular invasion, lymph node involvement, and stage by immunohistochemistry analysesResults: Among the 80 patients, 86.3% showed matrix metalloproteinase 11 expression in tumor cells and 17.5% had matrix metalloproteinase 11 expression in adjacent normal breast tissue. This expression correlated with stage, grade, lymph node metastasis, and perineural and vascular invasion (P0.05). Conclusion: Matrix metalloproteinase 11 expression is increased in breast cancer and may be used as a predictive factor for tumor invasiveness.
Middle East Journal of Cancer
Shiraz University of Medical Sciences
2008-6709
8
v.
2
no.
2017
69
75
https://mejc.sums.ac.ir/article_42068_5dea473c096a6f60f5d3fdb703712830.pdf
Evaluation of a Number of Blood Biochemical Markers after Radioiodine Therapy in Papillary Thyroid Cancer Patients
Mehrossadat
Alavi
Medical Imaging Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
author
Fatemeh
Zal
Biochemistry Department, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran
author
Fahimeh
Zamani
Biochemistry Department, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran
author
Mehdi
Kazemi
Nuclear Medicine Department, Shiraz University of Medical Sciences, Shiraz, Iran
author
Mozhgan
Rasti
Biochemistry Department, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran
author
text
article
2017
eng
Background: This study aimed to assess several biochemical and oxidative stress parameters before and after radioiodine therapy in patients with well-differentiated thyroid cancer who consumed a low iodine diet and withdrawal of levothyroxine after total thyroidectomy.Methods: We enrolled 40 candidates for radioiodine therapy. Blood sampling was performed prior to as well as 72 h after consumption of 125-200 mCi of 131I. Total protein, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and creatinine were measured. Oxidative stress parameters that included malondialdehyde and protein carbonyl levels were also assessed.Results: There were significantly decreased total protein, creatinine, aspartate aminotransferase, and alanine aminotransferase levels (P<0.001) after treatment. However, malondialdehyde levels increased significantly (P<0.05) over the studied time.Conclusion: We found that radioactive iodine absorption in peripheral tissues due to a low-iodine diet and levothyroxine withdrawal could relieve iodine deficiency in the liver and kidneys which resulted in reduced total protein, aspartate aminotransferase, alanine aminotransferase, and creatinine levels. However, it induced oxidative stress by increasing malondialdehyde levels in the blood.
Middle East Journal of Cancer
Shiraz University of Medical Sciences
2008-6709
8
v.
2
no.
2017
77
82
https://mejc.sums.ac.ir/article_42073_f1355093e75000dfea9531dd412b4309.pdf
Adjuvant Chemotherapy of Early Stage Breast Cancer in Community-based Cancer Treatment Fields: CMF Compared with Anthracycline/Taxane-based Regimens
Narges
Bayat Mokhtari
Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
author
Roham
Salek
Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
author
Fatemeh
Homaee Shandiz
Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
author
Soodabeh
Shahidsales
Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
author
text
article
2017
eng
Introduction: Mortality rate of breast cancer has been fallen in recent years. Combination of cyclophosphamide, methotrexate, and 5-fluorouracil(CMF), as a pioneer of adjuvant chemotherapy of breast cancer, and later introduced anthracycline/taxane(A/T)-based regimens have both produced favorable outcomes in early-stage breast cancer. The current study, aimed to evaluate the probably different outcomes between CMF and A/T regimens.Methods: In this cohort study, we extracted medical records of 1098 breast cancer patients referred to some oncology centers of Mashhad University of Medical Sciences from 1370 to 1390. Invasive cancers on stages I and II candidate for systemic chemotherapy were included. We categorized patients in the CMF and A/T arms and considered median event free survival (EFS), median overall survival (OS), 5- and 10-year EFS, and 5- and 10-year OS as the endpoints of the study.Results: In the CMF arm, median EFS was 190 months and the 5 and 10-year EFS were 77% and 61% respectively, while in the A/T arm, median EFS was 212 months and 5 and 10-year EFS were 74% and <61% respectively, without significant difference between two arms (P= 0.3). The 5 and 10-year OS were 87% and 76% in the CMF arm respectively, and 83% and <76% in the A/T arm respectively (p=0.2).Stage and estrogen receptor (ER) status significantly affected outcome in univariate analysis, however, the only important prognostic factor in multivariate analysis was the disease stage.Conclusion: Similar effectiveness exists between CMF and A/T-based regimens regarding outcomes of adjuvant treatment for early-stage breast cancer. We could be confident that CMF is more favorable due to infrequent side effects.
Middle East Journal of Cancer
Shiraz University of Medical Sciences
2008-6709
8
v.
2
no.
2017
83
91
https://mejc.sums.ac.ir/article_42074_de3c4988aaab9966fffbbec2dd482382.pdf
Examining the Predictive Role of Emotional Self-Regulation in Quality of Life and Perception of Suffering among Patients with Breast Cancer
Zahra
Nikmanesh
Department of Psychology, Faculty of Education and Psychology, University of Sistan and Baluchestan, Zahedan, Iran
author
Mahmoud
Shirazi
Department of Psychology, Faculty of Education and Psychology, University of Sistan and Baluchestan, Zahedan, Iran
author
Foroz
Farazinezhad
Psychiatric Hospital, Zahedan University of Medical Sciences, Zahedan, Iran
author
text
article
2017
eng
Background: Breast cancer is the most common type of cancer and second leading cause of death in women after lung cancer. The World Health Organization has reported that breast cancer, with 502,000 deaths in 2005, surpassed lung, stomach, colorectal, and cervical cancers as the leading cause of death in women. The main objective of the current study was to examine the predictive role of emotional selfregulation in quality of life and perception of suffering among patients with breast cancer.Methods: This was a descriptive-analytical study followed by a correlational design. The sample population consisted of 42 patients with breast cancer selected by the census method. Participants completed questionnaires on emotional self-regulation, quality of life (Aaronson et al., 1987), and perception of suffering. The obtained data was statistically analyzed using the Pearson correlation coefficient and regression analysis via SPSS 22.Results: There was a significant, positive association between emotional selfregulation and the functional and general dimensions of quality of life. A significant, inverse correlation existed between emotional self-regulation and the symptoms dimension of quality of life. The results of the enter regression analysis showed that selfregulation respectively predicted 0.18 of variance in the functional, 0.26 in symptoms, and 0.37 of the variance in the general health dimensions of the quality of life. Emotional self-regulation had a significant, diverse relationship to the physical, psychological, and existential dimensions of perception of suffering. The results of the regression analysis carried out to predict perception of suffering indicated that emotional self-regulation respectively predicted 0.33 of variance in the physical, 0.19 in psychological, and 0.06 of the variance in the existential dimensions of perception of suffering.Conclusion: A major step forward can be taken towards improving the level of quality of life among breast cancer patients through the use of books and educational brochures, individual and group counseling sessions associated with emotional self-regulation, and encouragement of patients to participate in cultural and sports activities.
Middle East Journal of Cancer
Shiraz University of Medical Sciences
2008-6709
8
v.
2
no.
2017
93
101
https://mejc.sums.ac.ir/article_42075_32f44a96bd73c72eea42e3dedee8256d.pdf
Geographic, Sex and Age Distribution of Esophageal Cancer Incidence in Iran: A Population-based Study
Salman
Khazaei
Department of Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran
author
Erfan
Ayubi
Department of Epidemiology, School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran
author
Kamyar
Mansori
Dezful University of Medical Sciences, Dezful, Iran
author
Behzad
Gholamaliee
Department of Public Health, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran
author
Somayeh
Khazaei
Department of Operating Room,School of Paramedicine, Hamadan University of Medical Sciences, Hamadan, Iran
author
Fatemeh
Khosravi Shadmani
Modeling in Health Research Center, Institute for Future Studies in Health, Kerman University of Medical Sciences, Kerman, Iran
author
Mokhtar
Soheylizad
Social Development and Health Promotion Research Center, Gonabad University of Medical Sciences, Gonabad, Iran
author
Mohadeseh
Sani
Department of public health, School of public health, Zabol University of Medical Sciences, Zabol, Iran
author
Shiva
Mansouri Hanis
Social Determinants of Health Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran
author
text
article
2017
eng
Background: Esophageal cancer is the second most common malignancy in Iranian men and third most common in Iranian women.The aim of this study is to discover the geographic distribution for age-standardized incidence rate of esophageal cancer among both genders in Iran.Methods: This ecological study used re-analysis medical records aggregated to provinces from the National Cancer Registry and Disease Control and Prevention Report of the Ministry of Health and Medical Education for esophageal cancer in 2008. For each province, we calculated the average annual age-standardized incidence rate.Results: Squamous cell carcinoma was the most common histological type of esophageal cancer in males (65.4%) and females (75%). The age-standardized incidence rate for esophageal cancer in Western, Northwest, Northern and Northeast provinces of Iran were higher than other provinces. We observed the highest agestandardized incidence rate in both genders in the 80-84 year age group with 147.5 in males and 114.5 in females.Conclusion: Given that the Western, Northwest, Northern, and Northeast provinces were hot zones for esophageal cancer in Iran, increased access to screening services and implementation of prevention programs should be considered.
Middle East Journal of Cancer
Shiraz University of Medical Sciences
2008-6709
8
v.
2
no.
2017
103
108
https://mejc.sums.ac.ir/article_42070_470278078380972a24bc6c8556b7429d.pdf
Non-Hodgkin’s Lymphoma Mimicking a Locally Advanced Renal Mass: A Case Report
Mehdi
Salehipour
Department of Urology, Shiraz University of Medical Sciences, Shiraz, Iran
author
Masood
Hoseinzadeh
Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran
author
Afshin
Molaei Sisakhti
Department of Urology, Shiraz University of Medical Sciences, Shiraz, Iran
author
Vahid
Abdol Mohammadi Parvin
Department of Urology, Shiraz University of Medical Sciences, Shiraz, Iran
author
text
article
2017
eng
Renal masses can be categorized as benign and malignant lesions. Among the renal malignancies, renal cell carcinoma is the most common malignancy. However, other rare malignant lesions should be considered in differential diagnosis. Primary renal lymphoma is quite rare and might be mistaken for renal cell carcinoma. Due to lack of lymphatic tissue in the kidney, pathogenesis of renal lymphoma is controversial. In the present case, a 75- year-old man presented with a locally advanced renal mass and after resection of the mass, a diagnosis of Non-Hodgkin’s lymphoma was confirmed.
Middle East Journal of Cancer
Shiraz University of Medical Sciences
2008-6709
8
v.
2
no.
2017
109
112
https://mejc.sums.ac.ir/article_42071_1b9fc20f8faa866275c7f98f4b0b9d00.pdf
Low-grade Myxofibrosarcoma in the Mandible: A Rare Case Report
Neda
Kargahi
Dental Research Center, Department of Oral and Maxillofacial Pathology, School of
Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
author
Elham
Arjang
Post-Graduate Student of Oral and Maxillofacial Pathology, School of Dentistry, Isfahan
University of Medical Sciences, Isfahan, Iran
author
Shirin
Shahnaseri
Dental Implant Research Center, Department of Oral and Maxillofacial Surgery, School
of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
author
Forooz
Keshani
Dental Research Center, Department of Oral and Maxillofacial Pathology, School of
Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
author
text
article
2017
eng
Myxofibrosarcoma is a malignant neoplasm of connective tissue origin commonly found in the extremities. It is very rare in the head and neck regions. Only 25 cases of myxofibrosarcoma have been reported in the head and neck regions until 2014. Here we report a 61-year-old male with this neoplasm in the lower border of his mandible. During a two-year follow-up, this case recurred four times despite a complete resection. This study suggested combined surgical and adjuvant radiotherapy for unresectable lesions and tumors with positive margins to prevent recurrence and risk of progression.
Middle East Journal of Cancer
Shiraz University of Medical Sciences
2008-6709
8
v.
2
no.
2017
113
116
https://mejc.sums.ac.ir/article_42072_ddae829ace9d2fb9dd7ba9f2cd3d2e84.pdf
Calendar of Events
text
article
2017
eng
Middle East Journal of Cancer
Shiraz University of Medical Sciences
2008-6709
8
v.
2
no.
2017
117
117
https://mejc.sums.ac.ir/article_42069_fed4f6f1c16d3e22e25b2e688f826581.pdf